Gestone 200 (Progesterone)

What are the Uses of Gestone 200 (Progesterone)?

Gestone 200 is commonly prescribed for:

• Luteal phase support in IVF or assisted reproductive techniques (ART)

• Hormonal support during early pregnancy

• Treatment of amenorrhea (absence of menstruation)

• Management of abnormal uterine bleeding

• Support in hormone replacement therapy (HRT) in menopausal women

• Preventing preterm birth in high-risk pregnancies (off-label)

What are the Benefits of Gestone 200 (Progesterone)?

• Helps maintain a healthy uterine lining for embryo implantation

• Supports early pregnancy by balancing estrogen effects

• Treats menstrual irregularities

• Aids in preventing miscarriage in women with progesterone deficiency

• Provides hormonal balance during HRT

• Helps prevent preterm labor in some cases

How Does Gestone 200 (Progesterone) Work?

Progesterone is a natural hormone that prepares the uterus for pregnancy and maintains it. Gestone 200 mimics this hormone by:

• Enhancing endometrial receptivity

• Supporting embryo implantation and early fetal development

• Counteracting the proliferative effect of estrogen on the uterine lining

• Regulating the menstrual cycle

How to Take Gestone 200 (Progesterone)?

• Route: Intramuscular (IM) or subcutaneous (SC) injection

• Timing: As prescribed by your doctor, often starting after ovulation or egg retrieval in ART

• Location: Usually administered in the buttocks or thigh

Dosage of Gestone 200 (Progesterone)?

Typical dosage depends on the indication:

• For IVF support: 25–100 mg/day via IM

• For amenorrhea: 5–10 mg/day for 6–10 days

• For hormone therapy: Dosage varies based on estrogen co-administration

Always follow your healthcare provider’s prescribed dosage.

Missed Dose and Overdose

• Missed dose: Administer as soon as you remember unless it’s near the time of the next dose. Do not double dose.

• Overdose: May cause drowsiness, dizziness, or hormonal imbalance. Seek emergency medical help if overdose is suspected.

What are the Available Strengths of Gestone (Progesterone)?

• Gestone 100 mg/ml

• Gestone 200 mg/ml

These are typically provided in ampoules for injection.

Side Effects of Gestone 200 (Progesterone)

Common:

• Pain or swelling at the injection site

• Breast tenderness

• Headache

• Mood changes

• Fatigue

Rare/Serious:

• Blood clots

• Allergic reactions

• Jaundice

• Vision changes

Interactions of Gestone 200 (Progesterone)

Gestone may interact with:

• CYP450 enzyme inducers (e.g., rifampin, phenytoin) — may decrease effectiveness

• Estrogen-containing medications

• Anticoagulants

• Herbal supplements like St. John’s Wort

Inform your doctor about all medications and supplements you are taking.

Precautions of Gestone 200 (Progesterone)

• Not recommended in patients with liver dysfunction, breast cancer, or thromboembolic disorders

• Use cautiously in patients with depression, diabetes, or asthma

• Not for use during breastfeeding without medical advice

• Regular monitoring may be required during treatment

Storage Information

• Store in a cool, dry place (below 25°C)

• Protect from light

• Do not freeze

• Keep out of reach of children

Availability in the US and Australia

• USA: Gestone may not be available under the same brand. Alternatives like progesterone in oil or Crinone (progesterone gel) are used.

• Australia: Availability is limited; similar progesterone products may be available by prescription under different brand names.

Frequently Asked Questions (FAQs)

Q1. Is Gestone 200 safe during pregnancy?

Yes, when prescribed, it helps support early pregnancy, especially in IVF or women with luteal phase defects.

Q2. Can Gestone delay periods?

Yes, it may delay menstruation as it supports the uterine lining. Periods usually start after stopping the injection.

Q3. How long does it take for Gestone to work?

It begins acting shortly after injection, but therapeutic effects depend on consistent use and clinical indication.

Q4. Are there oral alternatives to Gestone 200?Yes, micronized progesterone c

apsules like Utrogestan or Susten are often used orally or vaginally.

Q5. Does it cause weight gain?

Some women may experience mild water retention or bloating, but significant weight gain is uncommon.