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What is Tadalafil (Cialis)?

Tadalafil (Cialis) is taken by mouth either as needed before sexual activity or once daily for erectile dysfunction (ED). It’s also taken once daily to treat symptoms from an enlarged prostate (benign prostatic hyperplasia, or BPH). Tadalafil (Cialis) is available both as brand-name and generic tablets. Common side effects of this medication include headache and indigestion. Tadalafil (Cialis) does interact with some medications, such as heart and blood pressure medications, and taking them together could lead to very low blood pressure and dizziness.

How Tadalafil works?

Tadalafil works by increasing blood flow to the penis helping the spongy tissue of the penis fill up with blood, making it become harder.

In the human body, there’s a substance known as cGMP that relaxes smooth muscle tissues. When it affects the walls of blood vessels, those vessels dilate, allowing them to carry more blood and thus improving blood flow — the better the rate of blood flow to the penis, the stronger the erection.

However, an enzyme known as PDE5 can cause problems. When it encounters cGMP, it binds to it and breaks it down, rendering it ineffective. And while the root cause of erectile dysfunction can vary, blocking PDE5 always seems to be an effective treatment.

Tadalafil is a PDE5 inhibitor. When consumed, it stops PDE5 from breaking down cGMP as quickly or effectively. This allows the cGMP to have a much greater impact on blood flow, especially to the penis, majorly improving the user’s ability to achieve and maintain an erection.

How and when to take Tadalafil?

Tadalafil is an oral medication provided in tablets of 10mg and 20mg. Most men start off with 10mg tablets and find these effective. However, if you find that the 10mg tablets do not have the desired effect after trying around eight times, you can increase the strength to 20mg tablets.

Tadalafil tablets take at least 30 minutes to take effect so ideally, you need to take them around 60 minutes before you want to achieve an erection.

You shouldn’t take more than one tablet of Tadalafil in a 36-hour period, regardless of the strength of tablet you take.

If you take too much, it can greatly worsen the side effects of Tadalafil, causing intense chest pain, nausea, dizziness, and various other unpleasant symptoms.

Take a look at our dedicated Tadalafil side effects page if you have further questions.

What is tadalafil used for?

Tadalafil, or generic Cialis, is most commonly used to treat erectile dysfunction (ED). However, it’s also used to treat benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension.

Along with other medications used to treat ED, Cialis and generic tadalafil are only available by prescription.

Tadalafil, like other phosphodiesterase type 5 (PDE5) inhibitors, can interact dangerously with nitrate-based medications, such as Imdur and Nitrostat. This includes nitrates used to treat heart conditions and high blood pressure.

What if I miss a dose?

If you are taking this medication as needed for erection problems, this does not apply. If you miss a dose while taking this medication once daily for an erection problem, benign prostatic hyperplasia, or both, take it as soon as you remember, but do not take more than one dose per day.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions
  • Hearing loss or ringing in ears
  • Heart attack
  • Low blood pressure
  • painful erection
  • Redness
  • Stroke
  • Sudden vision loss in one or both eyes
  • Back pain
  • Facial flushing or redness
  • Headache
  • Muscle pain
  • Runny or stuffy nose
  • Upset stomach

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.

Drug-Drug Interactions

When tadalafil is taken with other drugs, it may cause undesirable consequences.

If you are taking any of the following medications, please let your doctor know.

Isosorbide dinitrate, isosorbide mononitrate, amyl nitrate, nitroglycerin, and other angina drugs

Alpha-blockers include Terazosin, Tamsulosin, Doxazosin, Prazosin, Alfuzosin, and so on.

medications that fight fungus, such as itraconazole and ketoconazole

medicines including clarithromycin, erythromycin, and telithromycin

Interactions between diseases

If you have any of the following conditions, taking tadalafil could have negative side effects:

  • a heart ailment
  • renal illness
  • respiratory conditions
  • hearing loss
  • Liver disease
  • Food-Related Issues

It is advised to stay away from foods like grapefruit and beverages like alcohol and grapefruit juice when taking a Tadalafil tablet, as they may have unfavorable effects.

What’s the difference between sildenafil (Viagra) and tadalafil (Cialis)?

Both sildenafil (Viagra) and tadalafil (Cialis) can be used for erectile dysfunction (ED), but there are some differences between them.

One difference is that tadalafil (Cialis) is approved to treat both ED and BPH whereas sildenafil (Viagra) can only be used for ED.

Another difference is that sildenafil (Viagra) seems to reach its peak effect more quickly, but tadalafil (Cialis) lasts longer.

A third difference is that sildenafil (Viagra) can only be used as needed for ED. But you have the option of taking tadalafil (Cialis) every day. Taking a daily dose of tadalafil (Cialis) might be a better option for people who prefer more spontaneity. For more about the differences between sildenafil (Viagra) and tadalafil (Cialis), talk with your provider.


What occurs when tadalafil is taken?

Men use Tadalafil tablets to treat erectile dysfunction (ED).

Because they are unable to achieve and maintain an erection during sexual engagement, men with ED suffer from sexual dysfunction.

By blocking PDE5, one can have an erection and have a more satisfying and joyful erotic experience in bed. 

What occurs if two Tadalafil tablets are taken?

Taking more Tadalafil than is recommended or more than one Tadalafil pill per day may result in a prolonged and uncomfortable erection.

Does Tadalafil mix well with alcohol?

No, drinking alcohol while taking a dose of Tadalafil is not advised since it may negatively impact your health.

This may also cause a drop in blood pressure, which could leave you dizzy.

Can I take half of Tadalafil?

No, it would be better if you completely consumed a tablet of Tadalafil while sipping a glass of water. It can’t be broken, chewed, or sliced.

Is Tadalafil OK for people with cardiac issues?

Tadalafil-containing medications may cause substantial and undesirable interactions in patients with cardiac problems. Therefore, before using this drug, it is imperative that you disclose to your doctor any past medical difficulties.

How quickly does tadalafil act?

Tadalafil pill effects usually take 30 to 60 minutes to become noticeable.

As a result, you ought to utilize it thirty to sixty minutes before having sex.

What are some of the most typical Tadalafil side effects?

Side symptoms include flushing, coughing, indigestion, nausea, and headaches are common with tadalafil.

What is the purpose of the Tadalafil tablet?

Male erectile dysfunction is treated with tadalafil pills (ED).

In addition, Benign Prostatic Hyperplasia (BPH) and Pulmonary Arterial Hypertension (PAH) are treated with tablets containing the salt Tadalafil.

What are the Tadalafil (Cialis) substitutes?